Y’s Jungle Gym

At the Y’s Jungle Gym program, kids age 1-5 are set free to tumble across the facility’s big, padded mats, crawl through tunnels, or jump wildly in the Moon Bounce that’s almost always set up. There are balance beams for small daredevils, bikes and space to ride them in, and arts and crafts activities for the kids who get tired. Parents supervise and participate, and there are staff members about to provide advice on equipment and lead activities.

The Jungle Gym is a great way for pre-preschoolers to get their ya ya’s out, particularly on rainy days, and all the equipment might inspire you to play, too. No grownups in the bounce house, though.

Jungle Gym takes place each Tuesday, Thursday, and Friday, 10:30am-noon at the Letterman Gym at the Presidio YMCA, 1152 Gorgas Avenue (at Marina Boulevard), in the Presidio, San Francisco. Call 415-447-9680 or visit ymcasf.org.

Amabile School of Music

http://www.amabilemusic.org/Home.html
Taraval and 29th
Disney Song and Dance (Ages 3-6 and 7-9)

- Learn about the different Disney characters and the songs their sing. This is a dance and voice

training program that will encourage students to work together as a team and be able to act and sing

as if they were a Disney Character! Some songs include: "Be our Guest" from Beauty and the Beast,

"Friend Like Me" and "A Whole New World" from Aladdin and "Under the Sea" from The Little

Mermaid.

Toddler’s Class (Age 3-4)

- Toddler’s Class is designed for 3 to 5-year-olds to start having fun with elements in music. The class explores basic musical concepts such as pitch, dynamics, tempo, and rhythm. The class includes fun activities of playing musical games, puzzles, drawing, singing and dancing. It is the perfect music introduction class for your children. Click to see a sample class syllabus Toddler's Syllabus.doc.

insulin-signalling pathway has a role in male differentiation.

The discovery of the role of Sry in male development was heralded as a great breakthrough and it became known as a classic master switch of development: XY vertebrates with functional Sry developed as males; those without it developed as females. Despite the initial excitement,however,working out what was upstream and downstream of this transcription factor proved very difficult. The insulin family signalling pathway comprises three receptors: Ir, Igf1r and Irr. Single mouse mutants at these loci do not show any abnormal sexual phenotype but, as the authors show by electron microscopy and histochemical analysis,XY triple mutants are completely feminized.
Despite the fact that sex determination mechanisms evolve rapidly, there is some degree of conservation in the pathways involved between invertebrates and vertebrates. As the insulin-signalling pathway is also present in worms and flies, Parada and colleagues call for using these organisms to identify further potential candidates in this pathway that have a role in male differentiation.
ORIGINAL RESEARCH PAPER
Nef, S. &Verma-Kurvari, S. et al. Testis determination requires insulin receptor family function in mice.
Nature 426, 291–295 (2003)
FURTHER READING Stadler, H. S. Modelling genitourinary defects in mice: an emerging genetic and developmental system. Nature Rev. Genet. 4, 478–482 (2003)

проект "Неизвестная планета".

Международный проект "Неизвестная планета"

ВИКТОРИНА "Неизвестной планеты"

Tonight we woke up at 4am from an eerie sound that seemed to come from outside. It turned out that our backyard irrigation system started working and the water pipes inside the house made the noise. The system is in place for two years now and never gave us any problem. Will have to investigate - here is a promising link.

New Skis!

Those are my new skis Volkl Attiva AC2 - Contruction Double Grip LT Core 20/20 Sensorwood (156, 116-72-103, 13.0). I also have Nordica OLYMPIA SM 8 boots. I went to test them on Alpine Meadows resort this Sunday. At first I saw a very big difference in how easy the skis were to control. I was so happy that I decided to go on some black diamonds - the first one was not too bad and I got extra bold. The one called "Waterfalls" made me realize that I need to work on my technique A LOT. I still did not give up and went on "The face"- moguls on a steep slope. This was a big mistake - I have spent a lot of time and energy to crawl down. After this I skied only on blue slopes for the rest of the day. It was really good!

Рукописные памятники Древней Руси

Открылся сайт gramoty.ru (не путать с gramota.ru!), представляющий вниманию ученых и широкой публики все ныне известные древнерусские берестяные грамоты.